Research chemicals only · Not for human use · DYOR

Peply Labs
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Immune / Skin

Thymosin Alpha-1

aka Tα1, Zadaxin

Approved immunomodulator for Hep B/C, sepsis, vaccines

MW (Da)

3,108.32

Half-life

~2 hr (active fragment longer)

Sequence

Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN

Storage

Lyophilized 2–8 °C. Reconstituted refrigerate.

Research chemicals only. Not for human use. For research and educational purposes only. Always do your own due diligence and consult qualified professionals.

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Safety at a glance

Full safety details

Most-reported side effects

  • Generally well tolerated
  • Injection site irritation

Don't use if…

  • Solid organ transplant on immunosuppression
  • Active autoimmune flare (caution)
  • Pregnancy

What it is

Synthetic 28-aa version of natural thymic hormone Thymosin α1. Approved in 30+ countries (e.g., Zadaxin) for chronic hepatitis, sepsis adjunct, vaccine adjuvant and immune support.

Mechanism of action

Activates TLR-9, restores T-cell/NK function, modulates dendritic cells, and rebalances Th1/Th2 immunity.

Reported benefits

  • Improved immune response to vaccines and chronic viral infection
  • Adjunct in oncology immunotherapy (research)
  • May reduce frequency of recurrent respiratory infections

Evidence notes

Multiple Phase III trials in HBV/HCV/sepsis showed efficacy or signal.