Research chemicals only · Not for human use · DYOR

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#4 popular
Emerging human
Growth Hormone
Longevity

CJC-1295

aka Modified GRF (1-29), CJC-1295 No-DAC, CJC-1295 with DAC

GHRH analog that drives natural pulsatile GH release

MW (Da)

3,367.94

Half-life

No-DAC ~30 min; with DAC ~6–8 days

Sequence

Modified GRF (1-29) tetra-substituted

Storage

Lyophilized: 2–8 °C. Reconstituted: refrigerate, 30 days (no-DAC) / 60 days (DAC).

Research chemicals only. Not for human use. For research and educational purposes only. Always do your own due diligence and consult qualified professionals.

Hover any underlined term for a plain-English definition.

Safety at a glance

Full safety details

Most-reported side effects

  • Tingling, head rush at injection
  • Water retention

Don't use if…

  • Active cancer
  • Severe insulin resistance / diabetes (monitor)
  • Pregnancy

What it is, in plain English

CJC-1295 tells your pituitary to make more of your own growth hormone, instead of injecting GH directly. There are two flavors: 'No-DAC' (also called Mod-GRF) gives you natural pulses like your body would make, and 'DAC' is a long-acting version that stays in your blood for a week. Most people want the No-DAC version paired with Ipamorelin — that combo is the standard 'GH stack' biohackers talk about.

Who tends to explore this

  • You're 35+ and noticing slower recovery, worse sleep quality, less muscle definition than a decade ago
  • You want the 'GH benefits' without injecting actual HGH (which is a federal-controlled-substance issue in the US)
  • You're stacking with Ipamorelin for the classic GH-pulse protocol

Who should skip this

  • Active or recent cancer — GH can fuel tumor growth
  • Untreated diabetes or fasting glucose >120 — GH temporarily worsens insulin sensitivity
  • Pregnancy or trying to conceive
  • If you don't know whether you want DAC or No-DAC, you're not ready to use this yet

What to expect — typical timeline

First few doses

A 'flushing' feeling — head warmth, slight tingling — usually within 5–10 minutes. Goes away as your body adapts.

Week 1–2

Deeper sleep is usually the first noticeable change. Some users report mild water retention.

Week 3–8

Improved recovery from training, slow lean-mass gains, better skin elasticity. IGF-1 bloodwork rises.

After cycle

Most users take 2–4 weeks off to let receptors reset before another cycle.

Individual responses vary widely. This is a typical pattern, not a guarantee.

Common beginner mistakes

  • Eating right before injection — GH release is blunted by carbs/insulin. Inject on empty stomach, wait 20–30 min before food
  • Confusing No-DAC and DAC — they have totally different dosing schedules. Always confirm which version you bought
  • Taking it with breakfast in the morning instead of pre-bed — pre-bed dosing better matches your natural GH rhythm
  • Skipping IGF-1 bloodwork — without baseline + on-cycle labs, you have no idea if your peptide is even working

Reported benefits

  • Increased lean mass, recovery, sleep depth and skin quality
  • Pulsatile (no-DAC) most physiological; DAC raises baseline IGF-1
  • Often paired with a GHRP for synergistic GH release