TB-500

aka Thymosin Beta-4 fragment 17–23, TB4-Frag

Systemic soft-tissue and vascular repair

MW (Da)

889.01

Half-life

~2–3 hr (synthetic fragment)

Sequence

LKKTETQ

Storage

Lyophilized: 2–8 °C. Reconstituted: refrigerate, 30 days.

Research chemicals only. Not for human use. For research and educational purposes only. Always do your own due diligence and consult qualified professionals.

Hover any underlined term for a plain-English definition.

Safety at a glance

Full safety details

Most-reported side effects

Lethargy in first weeks (tissue remodeling)
Mild flu-like 'healing' sensation

Don't use if…

Active cancer (pro-angiogenic)
Pregnancy

What it is, in plain English

TB-500 is a fragment of a natural healing protein. Where BPC-157 tends to work locally, TB-500 spreads through the whole body — making it the go-to choice for people with multiple injuries or full-body wear-and-tear. The two are often stacked together; this combo is nicknamed the 'Wolverine stack'.

Who tends to explore this

You have multiple injuries at once, or generalized soreness that BPC-157 alone hasn't resolved
You're an older athlete dealing with cumulative wear-and-tear
You want full-body recovery support during a heavy training block

Who should skip this

Active or recent cancer — same blood-vessel-growth concern as BPC-157
Pregnancy or breastfeeding
If the injury is highly localized to one tendon, BPC-157 alone is usually enough — TB-500 may be overkill

What to expect — typical timeline

Week 1–2 (loading)

Some users feel a mild sense of relaxation or reduced inflammation; many feel nothing yet.

Week 2–4

Soft-tissue healing typically becomes noticeable. Tendons feel less reactive, range of motion improves.

Week 4–6

Loading phase ends. Most people transition to maintenance dosing or stop entirely if recovered.

Individual responses vary widely. This is a typical pattern, not a guarantee.

Common beginner mistakes

Skipping the loading phase — TB-500 needs to build up; jumping straight to maintenance dosing rarely works
Stopping early because you don't feel a 'kick' — it's a slow background-healing peptide, not a stimulant
Not stacking with BPC-157 when treating an acute injury — synergy is real