SS-31

aka Elamipretide, Bendavia

Mitochondrial-targeted peptide for energy and cardiac support

MW (Da)

639.79

Half-life

~3 hr

Sequence

D-Arg-2',6'-dimethylTyr-Lys-Phe-NH2

Storage

Lyophilized 2–8 °C. Reconstituted refrigerate.

Research chemicals only. Not for human use. For research and educational purposes only. Always do your own due diligence and consult qualified professionals.

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Safety at a glance

Full safety details

Most-reported side effects

Injection-site reaction is most common
Possible transient nausea

Don't use if…

Pregnancy

What it is

An aromatic-cationic tetrapeptide that selectively concentrates in the inner mitochondrial membrane and binds cardiolipin—stabilizing electron transport and reducing reactive oxygen species.

Mechanism of action

Binds cardiolipin, restores supercomplex assembly in the ETC, reduces mitochondrial ROS, and improves ATP output without uncoupling.

Reported benefits

Improvement in mitochondrial-driven diseases (Barth syndrome, primary mitochondrial myopathy)
Investigated in heart failure, ischemia-reperfusion, age-related mitochondrial decline
Anecdotal energy and recovery benefits in biohacker dosing