Research chemicals only · Not for human use · DYOR

Peply Labs
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#6 popular
Emerging human
Cognitive / Nootropic

Semax

aka ACTH(4-10) analog Pro-Gly-Pro

Russian heptapeptide for focus, BDNF and stroke recovery

MW (Da)

813.93

Half-life

~30 min plasma; CNS effects last hours

Sequence

MEHFPGP

Storage

Reconstituted: refrigerate, 30 days. Common as nasal spray.

Research chemicals only. Not for human use. For research and educational purposes only. Always do your own due diligence and consult qualified professionals.

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Safety at a glance

Full safety details

Most-reported side effects

  • Nasal irritation
  • Mild headache

Don't use if…

  • Pregnancy
  • Severe psychiatric instability without supervision

What it is

Originally developed in Russia from an ACTH fragment. Approved in Russia for stroke and cognitive disorders. Known to dramatically increase BDNF and NGF and to modulate dopamine.

Mechanism of action

Modulates melanocortin and BDNF/TrkB signaling, increases dopamine D2 expression, inhibits enkephalin breakdown, and is neuroprotective in ischemic/stress models.

Reported benefits

  • Acute focus, motivation, mood lift
  • Reduced stress reactivity and mental fatigue
  • Used in Russian protocols post-stroke and TBI

Evidence notes

Russian-language Phase III data exist for stroke recovery. Western data limited. Biohacker community uses it heavily as a nootropic stack with Selank.