Research chemicals only · Not for human use · DYOR

Peply Labs
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Strong human
Cognitive / Nootropic

PT-141

aka Bremelanotide, Vyleesi

Melanocortin agonist for libido & sexual function

MW (Da)

1,025.18

Half-life

~2 hr

Sequence

Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH

Storage

Lyophilized 2–8 °C. Reconstituted refrigerate, 30 days.

Research chemicals only. Not for human use. For research and educational purposes only. Always do your own due diligence and consult qualified professionals.

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Safety at a glance

Full safety details

Most-reported side effects

  • Nausea (very common — start low)
  • Flushing

Don't use if…

  • Uncontrolled hypertension
  • Cardiovascular disease
  • Pregnancy

What it is

FDA-approved (2019) cyclic heptapeptide for hypoactive sexual desire disorder in premenopausal women. Acts centrally on the melanocortin system rather than peripherally on vasculature like PDE-5 inhibitors.

Mechanism of action

Non-selective melanocortin receptor agonist (MC1R/MC4R) within the hypothalamus, increasing dopamine release in mesolimbic reward circuitry.

Reported benefits

  • Centrally-mediated libido and arousal increase in both men and women
  • Functional even when PDE-5 inhibitors fail

Evidence notes

Two FDA-pivotal trials in HSDD. Off-label male use is anecdotally common.