Research chemicals only · Not for human use · DYOR

Peply Labs
Back to Research Hub
☀️
#15 popular
Anecdotal
Cognitive / Nootropic
Immune / Skin

Melanotan II

aka MT-II, MT2

Tanning peptide—powerful melanin stimulation, strong side effects

MW (Da)

1,024.18

Half-life

~33 hr (tissue)

Sequence

Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2

Storage

Lyophilized 2–8 °C. Reconstituted refrigerate.

Research chemicals only. Not for human use. For research and educational purposes only. Always do your own due diligence and consult qualified professionals.

Hover any underlined term for a plain-English definition.

Safety at a glance

Full safety details

Most-reported side effects

  • Severe nausea / flushing on first doses
  • New moles or darkening of existing moles (monitor!)

Don't use if…

  • Personal/family history of melanoma
  • Cardiovascular disease
  • Pregnancy

What it is

Non-selective melanocortin agonist used recreationally for sun-tan induction. Closely related to PT-141 but with stronger MC1R (pigmentation) and MC4R (libido/appetite) effects.

Mechanism of action

Activates MC1R on melanocytes (eumelanin synthesis) and MC4R / MC3R centrally (libido, appetite suppression).

Reported benefits

  • Pronounced tanning with much less UV exposure
  • Possible appetite suppression
  • Off-label libido boost

Evidence notes

No regulatory approval. Reports of new/changed moles and rare cardiovascular events. Carries the highest side-effect profile in this list — research only.