Research chemicals only · Not for human use · DYOR

Peply Labs
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#10 popular
Mostly preclinical
Anti-inflammatory
Immune / Skin

KPV

aka α-MSH(11-13)

Tiny anti-inflammatory tripeptide for gut and skin

MW (Da)

411.55

Half-life

~1 hr plasma

Sequence

KPV

Storage

Reconstituted refrigerate, 30 days.

Research chemicals only. Not for human use. For research and educational purposes only. Always do your own due diligence and consult qualified professionals.

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Safety at a glance

Full safety details

Most-reported side effects

  • Generally well tolerated
  • Possible flushing at higher doses

Don't use if…

  • Pregnancy

What it is

C-terminal tripeptide of α-MSH with potent anti-inflammatory activity in the gut, skin and joints—without the pigmentation effects of full α-MSH.

Mechanism of action

Inhibits NF-κB signaling, decreases pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) intracellularly. Improves epithelial barrier function in colitis models.

Reported benefits

  • IBD, ulcerative colitis, eczema and psoriasis support (animal models)
  • Often combined with BPC-157 for gut protocols
  • Topical use for chronic dermatitis

Evidence notes

Strong rodent data; small dermatology pilots. Considered safe at typical research doses.