Research chemicals only · Not for human use · DYOR

Peply Labs
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#18 popular
Mostly preclinical
Metabolic
Longevity

5-Amino-1MQ

aka 5-Amino-1-methylquinolinium

Small-molecule NNMT inhibitor (often grouped with peptides)

MW (Da)

—

Half-life

~4 hr (oral)

Sequence

Small molecule, not a peptide

Storage

Capsules, room temperature.

Research chemicals only. Not for human use. For research and educational purposes only. Always do your own due diligence and consult qualified professionals.

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Safety at a glance

Full safety details

Most-reported side effects

  • Mild GI upset
  • Possible flushing

Don't use if…

  • Pregnancy
  • Insufficient long-term safety data

What it is

A small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) — an enzyme over-expressed in obese adipose tissue and aged muscle. Sold alongside peptides; distinct chemistry.

Mechanism of action

Inhibits NNMT, raising cellular NAD+ and SAM availability and suppressing white adipocyte expansion. Improves muscle stem-cell regeneration in aged mice.

Reported benefits

  • Reduced fat-mass gain and improved insulin sensitivity in rodents
  • Restored muscle stem cell function in aged mice
  • Synergistic with NAD+ and exercise interventions

Evidence notes

Preclinical only. No IND/FDA approval. Sold as research compound.